儿茶酚胺(Catecholamine; CA)神经递质系统,主要位于前额叶皮层和基底神经节,在认知控制中发挥着关键作用,例如语言理解过程中的语义整合。然而,其在句法加工中的作用尚不明确。本研究考察了CA促进剂哌醋甲酯(MPH)对“花园路径”歧义句加工的影响。歧义句加工过程中,读者需要对句法进行重复的评估和分析,以达成正确理解。40名参与者完成了两次实验(MPH与安慰剂对照),在模糊、无歧义和控制条件下阅读句子,并记录了32个电极的EEG数据。首先,我们重复了此前研究的发现,歧义句相较无歧义句,引发了一个P600效应。最关键的是,MPH增加了歧义句条件下的P600效应的大小,而在无歧义条件或句子其它位置并未观察到类似效应。我们提出,CA水平的升高促进了句法加工,使得被试可以及时调整加工目标,优先处理句法信息。
The catecholaminergic (CA) neurotransmitter system, primarily in the prefrontal cortex and basal ganglia, plays a critical role in cognitive control, including semantic unification during sentence processing. However, its involvement in syntactic unification remains unexplored. This study examined the impact of a CA stimulant, methylphenidate (MPH), on the processing of garden-path sentences, which require syntactic revision. Forty participants completed two experimental sessions (MPH vs placebo), reading sentences in ambiguous, unambiguous, and control conditions. EEG was recorded from 32 electrodes. We replicated a P600 effect between the ambiguous and unambiguous sentences. Most important, MPH increased the size of the P600 effect in the ambiguous condition, though no such effect was observed in the unambiguous condition or early part of the sentences. We propose that elevated CA levels enhance the saliency of syntactic unification needs, facilitating real-time adjustment in processing goals and prioritizing syntactic information over others.
谭滢滢
谭滢滢,上海外国语大学语言科学研究院,本科毕业于北京大学心理学系,美国Rice University获得认知神经科学博士。2015-2020年间,在荷兰马克思普朗克研究所心理语言学中心从事博士后研究。主要研究领域为心理语言学和神经语言学,关注句法和语义加工的认知神经过程、语言加工与工作记忆及执行控制功能的交互影响、以及语言中情绪信息的认知加工过程等。通过综合运用心理语言学、神经成像、神经药理学和神经心理学(失语症)等多学科方法,揭示语言认知的复杂机制。以第一作者/通讯作者身份在Cerebral Cortex、Neuropsychologia等期刊发表多项研究成果,并担任Journal of Neroscience等国际期刊审稿人。入选上海市浦江人才计划,现主持国家自然科学基金青年项目、上海市自然科学基金面上项目等国家级与省部级科研项目。
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